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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Am J Surg Pathol. 2018 Jan;42(1):84–94. doi: 10.1097/PAS.0000000000000920

Figure 2.

Figure 2

Tumor cell necrosis exhibited an abrupt transition between viable to non-viable tumor without evidence of intervening tissue (A). In contrast, ischemic necrosis showed a zone of granulation tissue and/or hyalinization between viable and non-viable tumor (B). Tumor interface was classified as circumscribed when it was well-demarcated relative to surrounding non-neoplastic tissue or had an expansile growth (C) and as infiltrative when permeative growth or destructive invasion of surrounding tissue was present (D).