Table 3.

Pathologic Features of Recurrent Vaginal and Vulvar Smooth Muscle Tumors.

Case	Age	Site	Reported Diagnosis	Tumor Size (greatest dimension)	Degree of Atypia	Morphology	Mitotic Index (per 10 HPFs)	Atypical Mitotic Figures	Tumor Cell Necrosis	Ischemic Necrosis	Tumor Interface	Margin Status
42	67	Vagina	Myxoid leiomyosarcoma	4 cm	Moderate	Myxoid	6	Y	Y	Y	Infiltrative	Negative
43	44	Vagina	Leiomyosarcoma	6 cm	Moderate (pre-neoadjuvant biopsy and resection)	Epithelioid and focally spindled	18 (biopsy); 2 (resection)	Y	Y (pre-neoadjuvant biopsy and resection)	Y	Infiltrative	Focally positive
44	75	Vagina	Leiomyosarcoma	3.5 cm	Mild to moderate	Spindled	24	Y	Y	N	Circumscribed	Negative
45	64	Vagina	Leiomyosarcoma	9 cm	Moderate to severe	Spindled	14	Y	N	Y	Infiltrative	Negative
47	57	Vagina	Leiomyosarcoma	5.5 cm	Moderate to focally severe (pre-neoadjuvant biopsy); moderate to severe (resection)	Spindled	11 (pre-neoadjuvant biopsy); 4 (resection)	Y	Y	Y	Circumscribed	Negative
50	26	Vagina	Leiomyosarcoma	7 cm	Moderate to severe (pre-neoadjuvant biopsy and resection)	Spindled and myxoid	15 (pre-neoadjuvant biopsy); 2 (resection)	Y	Y (pre-neoadjuvant biopsy); N (resection)	Y	Infiltrative	Negative
51	62	Vagina	Leiomyosarcoma	6 cm	Severe	Spindled and focally myxoid	5	Y	Y	Y	Infiltrative	Diffusely positive
52	78	Vagina	Leiomyosarcoma	4.2 cm	Moderate to severe	Spindled	23	Y	Y	N	UNK	Diffusely positive
53	28	Vagina	Leiomyosarcoma	5 cm	Severe	Spindled	17	Y	N	N	UNK	Diffusely positive
69	72	Vulva	Leiomyosarcoma	11 cm	Moderate to severe	Epithelioid and spindled	8	N	Y	Y	Infiltrative	Focally positive
70	56	Vulva	Leiomyosarcoma	13.5 cm	Moderate to severe	Spindled and focally myxoid	34	Y	Y	Y	Infiltrative	Focally positive
71	68	Vulva	Leiomyosarcoma	5.5 cm	Moderate to severe	Spindled and focally myxoid	23	Y	Y	Y	Infiltrative	Negative

UNK (unknown); HPFs (high power fields)