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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Hypertension. 2017 Nov 13;71(1):199–207. doi: 10.1161/HYPERTENSIONAHA.117.10306

Figure 2.

Figure 2

MDSC adoptive transfer eradicates the hypertension, endothelial dysfunction, and vascular and renal injury in cyclosporine A-treated mice. A, Systolic blood pressure was measured prior to injections on days 1, 4, and 7 of treatment in mice given DMSO-saline vehicle (CON), cyclosporine A (CsA), and 1 million (1M) or 2 million (2M) MDSCs. Aortic relaxation responses to acetylcholine (B) and sodium nitroprusside (C) following contraction to phenylephrine were measured on day 8 following euthanization. D, Aortic fibronectin levels were measured by immunoblotting and normalized to the loading control actin. E, Representative glomeruli and glomerular injury index score for each group. F, Splenic regulatory T cell levels as determined by flow cytometry. Results are expressed as mean + SEM. *P<0.05 vs. Con and n=6–8 mice in each group. There were no significant group × treatment interactions as determined by 2-way ANOVA or repeated measures 2-way ANOVA.