Table 2.

Generalized linear latent and mixed models for systolic and diastolic blood pressure per $100\mathrm{mg}\mathrm{Na/L}$ lower water salinity.

Blood pressure	Model 1: Adjusted for age and sex			Model 2: Adjusted for age, sex, physical activity, smoking, BMI			Model 3: Adjusted for multiple confoundersa
	Difference in BP	$p-\text{Value}$	95% CI	Difference in BP	$p-\text{Value}$	95% CI	Difference in BP	$p-\text{Value}$	95% CI
Systolic
$100\mathrm{mg}\mathrm{Na/L}$ decrease (All)	$-0.89$	$<0.001$	$-1.14/-0.64$	$-0.92$	$<0.001$	$-1.16/-0.68$	$-0.95$	$<0.001$	$-1.20/-0.71$
Women	$-0.90$	$<0.001$	$-1.25/-0.55$	$-0.96$	$<0.001$	$-1.29/-0.63$	$-0.97$	$<0.001$	$-1.30/-0.63$
Men	$-0.93$	$<0.001$	$-1.28/-0.58$	$-0.92$	$<0.001$	$-1.27/-0.58$	$-0.90$	$<0.001$	$-1.25/-0.55$
Diastolic
$100\mathrm{mg}\mathrm{Na/L}$ decrease (All)	$-0.45$	$<0.001$	$-0.64/-0.26$	$-0.47$	$<0.001$	$-0.66/-0.28$	$-0.57$	$<0.001$	$-0.76/-0.38$
Women	$-0.38$	0.006	$-0.66/-0.11$	$-0.44$	0.001	$-0.71/-0.17$	$-0.55$	$<0.001$	$-0.82/-0.28$
Men	$-0.49$	$<0.001$	$-0.76/-0.23$	$-0.51$	$<0.001$	$-0.77/-0.25$	$-0.60$	$<0.001$	$-0.87/-0.33$

Note: Covers baseline, follow-up 1, and follow-up 2 measurements for each participant; one random effect per person, village, and subdistrict. BMI, body mass index; BP, blood pressure; CI, confidence interval.

^aAdjusted for age; sex; physical activity; smoking status; BMI; maximum daily temperature; underlying disease; marital status; religion; number household members; education; use of paan, hukka, and gul; water treatment; dietary salt intake; socioeconomic status; exposure to insecticides and chemical manure; and important changes in life.