Table 3.

Multivariate Cox regression analysis of DFS for clinical parameters and the combinations of low SHP2 and high nuclear STAT3.

Variables	HR (95% CI)	P-value
SHP2_Lo and STAT3_Hi vs SHP2_Hi or STAT3_Lo	2.353 (1.199–4.619)	0.013
Age (>50 vs ≤50)	0.701 (0.326–1.507)	0.363
TNM (III vs I + II)	1.347 (0.673–2.694)	0.400
Sex (women vs men)	0.410 (0.197–0.854)	0.017
Disease location (colonvs rectum)	0.863 (0.435–1.713)	0.674
Adjuvant chemotherapy (yes vs no)	1.807 (0.611–5.345)	0.285
Serum CEA (ng/ml) (≥5 vs <5)	1.806 (0.921–3.541)	0.085
Serum CA19-9 (U/mL) (≥37 vs <37)	1.189 (0.498–2.840)	0.696