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. 2017 Dec 14;8:2129. doi: 10.1038/s41467-017-01929-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Distribution of the interaction parameters of the GPDI model. For simple interpretation, GPDI parameters are presented as %-change of the EC50 of the victim drug caused by the perpetrator drug at EC50 (points); dashed lines indicate additivity for Loewe Additivity (a, c), and Bliss Independence (b, d); the additivity margin (square) was determined from sham combinations (crossed points) with Loewe Additivity; the sectors indicate bidirectional synergy (SYN), bidirectional antagonism (ANT) or the two possible asymmetric interactions (SYN + ANT); color coding indicates result from corresponding conventional interaction analysis, i.e., isobologram (a, b), Greco model (c), and empiric Bliss model (d), and their determined interaction, i.e., synergy (turquoise), additivity (blue) or antagonism (magenta)