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. 2017 Dec 14;8:2129. doi: 10.1038/s41467-017-01929-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Comparison of the GPDI parameters to estimates of conventional methods. Scatter plots of the parameter α of the Greco model vs. the Loewe Additivity-based GPDI model parameters INT_AB, expressed as % change of the EC50 of drug A (red) and INT_BA, expressed as % change of the EC50 of drug B (blue) (a), the parameter β of the empiric Bliss Independence model vs. the Bliss Independence-based GPDI model parameters (b), and α vs. β (c); correlation of the parameters was (r ²) 0.26 (a), 0.24 (b), and 0.59 (c)