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. 2017 Dec 14;8:2129. doi: 10.1038/s41467-017-01929-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Perpetrator and victim behavior. Interaction network between the significant interactions from the exclusively joined Loewe Additivity and Bliss Independence-based GPDI analyses (a); arrows visualize direction of the PD interaction from the perpetrator drug to the victim drug, i.e., decrease of the victims EC50 resulting in antagonism (magenta) or increase of the victims EC50 resulting in synergism (turquoise); note that interactions can be mono-directional or bi-directional of same polarity (joint antagonism or joint synergy) or opposite polarity leading to asymmetric bidirectional interactions; frequency of perpetrator and victim behavior in the network is presented in b, to d. Abbreviations of the compounds: Aureobasidin A (AbA), Amphotericin B (AmB), Anisomycin (Ani), Benomyl (Ben), Bromopyruvate (Bro), CCCP (C3P), Calyculin A (Cal), Cantharidin (Can), Chlorzoxazone (Chl), Cisplatin (Cis), Clo (Clozapine), Cycloheximide (Cyc), Dyclonine (Dyc), Fenpropimorph (Fen), Haloperidol (Hal), Hygromycin (Hyg), Latrunculin B (Lat), Lithium (Lit), Methotrexate (Met), Methyl methanesulfonate (MMS), Myriocin (Myr), Pentamidine (Pen), Quinine (Qnn), Quinomycin (QMY), Radicicol (Rad), Rapamycin (Rap), Staurosporine (Sta), Tacrolimus (Tac), Tamoxifen (Tam), Tunicamycin (Tun), and Wortmannin (Wor)