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. 2017 Dec 14;7:17600. doi: 10.1038/s41598-017-17928-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SCARF-1 forms an adhesive cup for CD4⁺ T cell adherence to HSEC. (a–d) Representative image of CD4⁺ T cells (blue; Cell Trace Violet (CTV)-labelled) attached to TNFα-stimulated HSEC (green; Cell Tracker Green (CTG)-labelled) via SCARF-1 (red) adhesive cups, which are rich in (c) filamentous (F-)actin (pink) and (d) ICAM-1 (grey). (a) White arrows highlight adherent CD4⁺ T lymphocytes. Scale bar = 40 µm. (b) White dotted line represents the periphery of the HSEC and the white dashed line delineates the site of the Z stack. Scale bars = 12 µm (left) and 2 µm (right). (c) White arrow highlights adherent CD4⁺ T lymphocyte. Scale bars = 22.5 µm (top left) and 7 µm (right). (d) White arrows highlight adherent CD4⁺ T lymphocytes. Scale bars = 50 µm (top left) and 5 µm (right). (c and d) White asterisks indicate adherent CD4⁺ T lymphocyte in adhesive cup.