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. 2017 Dec 14;7:17600. doi: 10.1038/s41598-017-17928-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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siRNA knockdown of SCARF-1 in HSEC significantly decreases CD4⁺ T cell adherence. (a) Representative Western blot analysis of SCARF-1 ~180 kDa and ~90 kDa species in HSEC treated with control and SCARF-1 siRNA knockdown. Results are regions cropped from the same membrane (see Supplementary Figure 7) (b) Quantification of SCARF-1 expression in HSEC treated with siRNA knockdown of SCARF-1 expressed as a % of expression in control HSEC. n = 3 independent experiments with different HSEC. *Indicates statistical significance where p ≤ 0.05. (c) Quantification of adherence of lymphocytes to monolayers of HSEC in flow assays pre-treated with control siRNA and SCARF-1 siRNA. n = 3 independent experiments with different HSEC donors, with 12 fields of view taken from each. ****Indicates statistical significance where p ≤ 0.001.