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. 2017 Dec 14;7:17608. doi: 10.1038/s41598-017-17962-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Accelerated retinal astrocytic differentiation in APC specific Hif-2α knockout mice. Retinas were isolated from Hif-2α ^flox/flox (f/f) and Hif-2α ^flox/flox/GFAPCre (KO) mice at P1. After whole-mount staining with anti-Pax2 and anti-GFAP and fluorophore conjugated secondary antibodies, retinas were flat mounted and imaged by confocal microscopy. Boxed areas were quantified for astrocytic differentiation, and data are shown in (G,H, and I). n = 5 mice. **p < 0.01, ***p < 0.001. Error bars represent SEM. Scale bars are 100 µm.