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. 2017 Dec 14;7:17553. doi: 10.1038/s41598-017-17875-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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mRNAs profile of microarray data. (A), Volcano plot of differentially expressed mRNAs in KBD chondrocytes compared to normal controls. Red points represent significantly up-regulated and green points represent significantly down-regulated mRNAs in KBD with a greater than 2.0-fold change. (B), Two-dimensional hierarchical clustering of distinguishable mRNA expression profiles in KBD chondrocytes compared with normal controls. Red: higher expression levels; green: lower expression levels. Probes are in rows, and samples are in columns. (C), Distribution of differentially expressed mRNAs in KBD, showing up-regulated (black) and down-regulated (gray) mRNAs in each chromosome (ch).