Table 2.
Selected up- and downregulated transcripts involved in insulin signalling and mitochondrial function in L6 myotubes after 24 h treatment with 60 μM test compounds.
| Gene Symbol | Accession | GR24 | Pinosylvin | Resveratrol | |||
|---|---|---|---|---|---|---|---|
| Fold change | Adj. p value | Fold change | Adj. p value | Fold change | Adj. p value | ||
| Insr | NM_017071 | 1.98 | 1.08 × 10 −6 | 1.03 | 7.75 × 10−1 | 1.14 | 9.99 × 10−2 |
| Irs1 | NM_012969 | 1.35 | 1.30 × 10 −2 | 1.11 | 4.23 × 10−1 | 1.33 | 1.30 × 10 −2 |
| Pik3c3 | NM_022958 | 1.68 | 9.20 × 10 −7 | 1.02 | 7.55 × 10−1 | 1.00 | 9.72 × 10−1 |
| Pdpk1 | NM_031081 | 1.66 | 9.30 × 10 −5 | 0.99 | 9.41 × 10−1 | 1.07 | 5.61 × 10−1 |
| Akt2 | NM_017093 | 0.85 | 3.28 × 10 −3 | 0.99 | 8.63 × 10−1 | 0.86 | 1.36 × 10 −2 |
| Slc2a4 | NM_012751 | 0.45 | 2.08 × 10 −7 | 1.22 | 8.71 × 10 −3 | 0.96 | 6.30 × 10−1 |
| Cast | NM_053295 | 1.76 | 3.26 × 10 −4 | 0.90 | 5.91 × 10−2 | 1.14 | 3.60 × 10−1 |
| Cs | NM_130755 | 1.47 | 5.35 × 10 −6 | 1.06 | 3.21 × 10−1 | 1.13 | 3.50 × 10 −2 |
| Immt | NM_001034928 | 1.28 | 7.59 × 10 −4 | 1.04 | 5.76 × 10−1 | 1.00 | 9.71 × 10−1 |
| Mrpl2 | NM_001034136 | 1.79 | 6.14 × 10 −7 | 1.11 | 9.45 × 10−2 | 1.19 | 1.14 × 10 −2 |
| Pc | NM_012744 | 1.64 | 4.98 × 10 −7 | 1.34 | 1.72 × 10 −4 | 1.59 | 1.03 × 10 −5 |
| Sdha | NM_130428 | 1.12 | 1.23 × 10 −2 | 1.08 | 1.31 × 10−1 | 1.00 | 9.54 × 10−1 |
| Tfam | NM_031326 | 1.79 | 1.58 × 10 −6 | 1.11 | 1.46 × 10−1 | 1.14 | 6.10 × 10−2 |
Insr, insulin receptor; Irs1, insulin receptor substrate 1; Pik3c3, phosphatidylinositol 3-kinase catalytic subunit type 3; Pdpk1, 3-phosphoinositide dependent protein kinase 1; Akt2, AKT serine/threonine kinase 2; Slc2a4, solute carrier family 2 member 4 (GLUT4); Cast, calpastatin; Cs, citrate synthase; Immt, inner membrane mitochondrial protein; Mrpl2, mitochondrial ribosomal protein L2; Pc, pyruvate carboxylase; Sdha, succinate dehydrogenase subunit A; Tfam, transcription factor A mitochondrial; Fold change shown for treated vs control groups, positive values reflect upregulation and negative values (shown in italics) reflect downregulation; Adj. p value, p value after Benjamini-Hochberg FDR correction, significance threshold set at p < 0.05, significant values shown in bold.