Table 1.

Kinetic constants for metabolic transformation of AA to GA and elimination of GA.

Metabolic pathway	Human S9			Rat S9
	Vmax (SE)c, nmol·mg protein−1·min−1	Km (SE), mM	EEd	Vmax (SE), nmol·mg protein−1·min−1	Km (SE), mM	EE
aAA to GA	0.053 (0.007)	0.11 (0.06)	0.50	0.060 (0.004)	0.029 (0.007)	2.1
bGA elimination	1.6 (0.7)	0.026 (0.02)	62	0.26 (0.02)	0.0060 (0.001)	43

^a n = 8 × 2.

^b n = 7 × 2.

^cStandard error in parenthesis.

^dEE = V_max/K_m, μL·mg protein⁻¹·min⁻¹.