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. 2017 Dec 14;7:17571. doi: 10.1038/s41598-017-17931-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression analysis of OAS1 in PBMC. (A) The schismatic figure shows the relative location of rs10774671 and OAS1 gene. Pairs of primers, OAS1_F and OAS1_R for detecting total expression of OAS1 were indicated. (B,C) The effect of SS-associated rs10774671 on OAS1 mRNA expression in healthy controls and SS cases was determined by RT-qPCR, respectively. Each data point represents an individual subject, and the bars show the standard deviation (SD). P values were calculated by using one-way ANOVA. (D) The comparison of OAS1 expression in PBMC between anti-SSA positive and anti-SSA negative SS cases. (E) 12 EBV-transformed B cell lines with various genotypes at 10774671 were stimulated by IFNα. Statistically differences between three groups were calculated by one-way ANOVA. P value < 0.05 was considered significant.