Table 2.
Prostate measurements (pre-plan) and conduct of treatment in the whole study population and in subgroups, by different Ablatherm® HIFU devices, occurrence of prostate edema, or patient movement.
| Measurements | Total (n = 327) | Ablatherm® HIFU devices |
Prostate edema |
Patient movement |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Device A1a(n = 139) | Device A2a(n = 188) | p-value | Yes (n = 43) | No (n = 284) | p-value | Yes (n = 63) | No (n = 264) | p-value | ||
| TRUS-measurements (pre-plan) | ||||||||||
| Prostate volume (mL) | 18 (14.0–22.0) | 19 (13.5–24.0) | 18 (14.0–21.0) | 0.033 | 21 (18.0–24.5) | 17 (13.0–21.0) | 0.001 | 18 (13.0–21.6) | 18 (14.0–22.0) | 0.985 |
| Prostate height (mm) | 22 (19.0–25.0) | 23 (20.0–25.0) | 20 (18.0–24.0) | <0.001 | 24 (20.5–25.8) | 21 (18.0–24.0) | 0.006 | 21 (18.0–24.0) | 21 (18.0–24.0) | 0.877 |
| Block strategy | <0.001 | <0.001 | 0.480 | |||||||
| 2 blocks | 194 (59.3) | 63 (45.3) | 131 (69.7) | 17 (39.5) | 177 (62.3) | 35 (55.6) | 159 (60.2) | |||
| 3 blocks | 128 (39.1) | 71 (51.1) | 57 (30.3) | 22 (51.2) | 106 (37.3) | 28 (44.4) | 100 (37.9) | |||
| 4 blocks | 5 (1.5) | 5 (3.6) | 0 | 4 (9.3) | 1 (0.4) | 0 | 5 (1.9) | |||
| Approach | <0.001 | 0.046 | 0.031 | |||||||
| Standard | 234 (71.6) | 83 (59.7) | 151 (80.3) | 25 (58.1) | 209 (73.6) | 38 (60.3) | 196 (74.2) | |||
| With adjustments | 93 (28.4) | 56 (40.3) | 37 (19.7) | 18 (41.9) | 75 (26.4) | 25 (39.7) | 68 (25.8) | |||
| Metric treatment data | ||||||||||
| Duration (min) | 145 (125–175) | 165 (135–200) | 135 (120–155) | <0.001 | 160 (135–190) | 145 (121–170) | 0.006 | 150 (130–180) | 145 (120–170) | 0.090 |
| Lesions (No.) | 589 (505–676) | 629 (505–759) | 571 (504–644) | 0.008 | 635 (550–697) | 580 (497–668) | 0.024 | 598 (516–701) | 586 (500–670) | 0.463 |
| Tx-volume (mL)b | 37.9 (31.0–44.0) | 40.5 (32.0–50.2) | 36 (30.0–41.0) | <0.001 | 42 (36.5–46.5) | 37 (31.0–43.0) | 0.003 | 38 (31.0–45.5) | 37 (31.0–44.0) | 0.659 |
| Tx-ratioc | 2.1 (1.8–2.6) | 2.1 (1.7–2.8) | 2.1 (1.8–2.4) | 0.864 | 2 (1.7–2.5) | 2.1 (1.8–2.6) | 0.264 | 2.1 (1.7–2.7) | 2.1 (1.7–2.5) | 0.594 |
| Anesthesia | 0.039 | 0.590 | 1.000 | |||||||
| Spinal | 295 (90.2) | 131 (94.2) | 164 (87.2) | 38 (88.4) | 257 (90.5) | 57 (90.5) | 239 (90.2) | |||
| General | 32 (9.8) | 8 (5.8) | 24 (12.8) | 5 (11.6) | 27 (9.5) | 6 (9.5) | 26 (9.8) | |||
Values are median (interquartile range) or n (%).
a
A1 = Ablatherm Maxis®, A2 = Ablatherm Integrated Imaging®.
b
Treatment-volume (computed sum of single lesion volumes).
c
Treatment ratio (treatment volume/calculated volume [pre-plan]).