FIG 7.

Comparison of chNHE1, ECL1, and the receptors of other ALV subgroups and retroviruses. Putative topology of ECL1 and the connected TM domains of chNHE1 are shown. The ALV-J gp85 contour is shown in blue in the size of an HIV-1 gp120 molecule. The identified binding sites on receptors are colored red. The receptors shown are the following: ALV-A, Tva; ALV-J, chNHE1; HIV-1, CD4; ALV-B, -D, and -E, Tvb; ALV-C, Tvc; EIAV, ELR1; and FIV, CD134. CD4 is shown in complex with HIV-1 gp120 (PDB entry 1GC1). The structural modeling of the receptors was generated using SWISS-MODEL and was based on homology molecules found in the PDB database.