PrPΔOR expression in the brains of Tg(PrPΔOR)/Prnp0/0 and Tg(PrPΔOR-3608)/Prnp0/0 mice. (A, left panel) Western blotting with 6D11 anti-PrP Ab of the brains of WT (n = 3), Tg(PrPΔOR)/Prnp0/0 (n = 3), and Prnp0/0 (n = 3) mice. (Right panel) Expression levels of PrPΔOR in Tg(PrPΔOR)/Prnp0/0 mice compared to PrPC in WT mice. (B, left panel) Western blotting of the brains of WT (n = 3), Prnp+/0 (n = 3), Tg(PrPΔOR-3608)/Prnp0/0 (n = 3), and Prnp0/0 (n = 3) mice with 6D11 anti-PrP Ab. (Right panel) Expression levels of PrPC in Prnp+/0 mice and PrPΔOR in Tg(PrPΔOR-3608)/Prnp0/0 mice compared to PrPC in WT mice. AU, arbitrary units.