Similar pathologies in the brains of terminally ill WT and Tg(PrPΔOR)/Prnp0/0 mice infected with RML, 22L, or BSE prions. Brain slices from uninfected (A) and RML (B)-, 22L (C)-, and BSE (D)-infected terminally ill WT (n = 3 in each mouse group) and Tg(PrPΔOR)/Prnp0/0 (n = 3 in each mouse group) mice were subjected to hematoxylin-eosin staining. Three sections from each mouse brain were used for the pathological examinations. Cx, cerebral cortex; Hp, hippocampus; Th, thalamus; Cb, cerebellum. Size bars, 100 μm.