TABLE 3.
Tg(PrPΔOR)/Prnp0/0 mice are still susceptible to RML and 22L prions, but highly resistant to BSE prions, even after secondary inoculation with RML-, 22L-, and BSE-infected Tg(PrPΔOR)/Prnp0/0 brain homogenates
| Tg(PrPΔOR)/Prnp0/0 brain homogenate inoculum | Recipient mice | No. of diseased mice/total | Incubation time (days)a | Survival time (days)b | P valuec |
|---|---|---|---|---|---|
| RML | WT | 10/10 | 144 ± 3 | 176 ± 7 | >0.3 |
| Tg(PrPΔOR)/Prnp0/0 | 10/10 | 145 ± 7 | 164 ± 15 | ||
| 22L | WT | 10/10 | 148 ± 6 | 155 ± 4 | <0.0001 |
| Tg(PrPΔOR)/Prnp0/0 | 10/10 | 104 ± 7 | 109 ± 3 | ||
| BSE | WT | 6/6 | 165 ± 8 | 179 ± 9 | <0.001 |
| Tg(PrPΔOR)/Prnp0/0 | 6/6 | 307 ± 9 | 331 ± 20 |
a
Time to onset of disease (average ± SD).
b
Time to terminal stage of disease (average ± SD).
c
P values indicate significance of comparison of incubation and survival times between Tg(PrPΔOR)/Prnp0/0 and WT mice by log rank (Mantel-Cox) test.