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Derivation of Candid#1 (13). (Top) Passage history and selected intermediate isolates. GP, passages in guinea pigs; MB, passages in mouse brain; FRhL, passage in fetal rhesus lung epithelium cell culture. Virulence (v) or attenuation (a) in the respective species is shown below. (Bottom) Amino acid substitutions detected in GPC. Position 427 in GP2 is highlighted. The ectopically expressed MC2 GPC utilized in the present studies is identical to the XJ13 progenitor at these positions.
