Figure 8. Effect of loop extrusion on the simulated chromatin surface area, volume, and inter‐chromosomal interactions.

• Representative polymer conformations of simulated chromatin undergoing loop extrusion. The rendered surface is the alpha shape (concave hull polygon) created using spheres centered on chromosome monomers. The monomers have radius 75 nm, which were chosen to be equal to the simulated Hi‐C capture frequency. With increasing cohesin density and processivity, the chromosome compacts and becomes more linearly ordered and the concave hull surface becomes “smoother”.