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. 2016 Sep 23;3(4):260–267. doi: 10.1016/j.ajur.2016.09.009

Figure 1.

Figure 1

Reversible EMT mediates metastasis of basal bladder cancers. Cells from orthotopic UM-UC3 tumors expressed higher levels of “epithelial” biomarkers than did circulating tumor cells (CTCs) harvested from tumor-bearing animals. The CTCs expressed particularly high levels of the EMT transcription factor, SNAIL (SNAI1). Interestingly, expression of EMT biomarkers returned to baseline in established metastases. Very similar observations were made previously by Tsai et al. [49] in a mouse model of squamous cell carcinoma. Based on Roth et al., Oncotarget 2016 [59]. CAFs, cancer-associated fibroblasts; EMT, epithelial-to-mesenchymal transition.