Table 1.

Molecular subtypes of bladder cancer.

TCGA	Lund	MDACC	UNC	Properties
Cluster I	UroA, GU	Luminal	Luminal	FGFR3 mutations, papillary features
Cluster II	Infiltrated	P53-like	Luminal	CAFs, immune cells
Cluster III	SCC-like, UroB	Basal	Basal-like	Stem cell biomarkers, squamous features
Cluster IV	Infiltrated	P53-like	Claudin-low	EMT, CAFs, immune cells

Transcriptome profiling and unsupervised analyses were used by several groups to identify candidate molecular subtypes of bladder cancer. Cross comparisons of the results obtained by 4 of the groups are presented above as examples. These comparisons are meant to be illustrative rather than definitive, but they show how the overall concordance among the approaches was very high. Also see Aine et al., Sci Rep 2015 [37] for a more detailed analysis.