Table II.
Differentially expressed genes that overlap with genes from the Comparative Toxicogenomic Database (CTD; http://ctdbase.org/) associated with the term “Bisphenol A” and the listed Diseases. The term “Cardiovascular Diseases” (9th row) includes: Hypotension (52 genes), Arrhythmias Cardiac (18), Hypertension (172), Myocarditis (5), Ventricular Premature Complexes (1), Vascular Diseases (16), Atherosclerosis (50), Cardiomegaly (64), Heart Defects Congenital (30), and Cardiomyopathy Hypertrophic (20 genes). Gene names and functions not mentioned in the text are listed in footnote1.
| Genes from CTD: BPA & Disease (# genes) | BPA vs Control (75) | C+OF vs Control (122) | BPA+OF vs C+OF (98) |
|---|---|---|---|
| Bisphenol A & Heart Failure (76) | 1 (ADRB3) | 2(ADRB3, GATM) | 1 (GATM) |
| Bisphenol A & Cardiomyopathies (65) | 0 | 1 (FAS) | 0 |
| Bisphenol A & Myocardial Infarction (82) | 0 | 0 | 1 (S100B) |
| Bisphenol A & Myocardial Ischemia (167) | 0 | 2(GATM, HSPA1A) | 3(GATM, TFRC, UQCRFS1) |
| Bisphenol A & Ventricular Dysfunction, Left (13) | 0 | 1(FAS) | 0 |
| Bisphenol A & Cardiomegaly (64) | 1 (UCP2) | 0 | 0 |
| Bisphenol A & Hypertension (172) | 5 (APOA1, FOS, NCF1, RGS2, UCP2) | 3 (FOS, NCF1, STK39) | 0 |
| Bisphenol A & Obesity (148) | 2 (ADRB3, UCP2) | 1 (ADRB3) | 2 (ALDH1L1, TFRC) |
| Bisphenol A & Cardiovascular Diseases (325) | 5 (APOA1, FOS, NCF1, RGS2, UCP2) | 5 (DRD1, FOS, HSPA1B, NCF1, STK39) | 2 (DRD1, MAOB) |
| Bisphenol A (273) | 5 (APOA1, EGR1, FOS, LPAR1, TH) | 2 (FAS, FOS) | 2 (C3, FABP4) |
ALDH1L1 (aldehyde dehydrogenase 1 family, member L1) loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression; APOA1 (apolipoprotein A–I) promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters; C3 (complement component 3) C3 peptide modulates inflammation and possesses antimicrobial activity; DRD1 (dopamine receptor D1) this G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases; GATM (glycine amidinotransferase) catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine which plays a vital role in energy metabolism in muscle tissues; HSPA1B (heat shock 70kDa protein 1B) participate in stabilizing of existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles; LPAR1 (lysophosphatidic acid receptor 1) plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents; MAOB (monoamine oxidase B) the protein catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues; NCF1 (neutrophil cytosolic factor 1) the protein is subunit of neutrophil NADPH oxidase; STK39 (serine threonine kinase 39) acts as a mediator of stress-activated signals; TFRC (transferrin receptor) participates in cellular iron uptake by the process of receptor-mediated endocytosis; TH (tyrosine hydroxylase) protein is involved in the conversion of tyrosine to dopamine and plays a role in the physiology of adrenergic neurons; UCP2 (uncoupling protein 2) protein separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat - mitochondrial proton leak; UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) ubiquinol-cytochrome c reductase complex is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.