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. 2017 Sep 7;32(1):289–303. doi: 10.1096/fj.201700252RR

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Figure 6. — FFAR2-FFAR3 heteromer displays signaling that is distinct from parent homomers. Heteromer displays enhanced intracellular Ca²⁺ signaling (1.5-fold increase relative to homomeric FFAR2) and β-arrestin-2 recruitment (30-fold increase relative to homomeric FFAR3) while losing ability to inhibit cAMP production. These heteromer-mediated enhancements were attenuated by FFAR2 antagonism (CATPB), G_αq inhibition (YM254890), or G_αi inhibition (pertussis toxin). Heteromerization also enabled p38 phosphorylation via CATPB- and YM254890-sensitive mechanism.