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. 2017 Aug 31;32(1):52–62. doi: 10.1096/fj.201700375R

Figure 5.

Figure 5.

Bzb preserves trabecular Ob.N and bone-forming activity after SARRP radiation. A) Ob.N/BS was measured in the distal femur trabecular region from WT mice treated with either vehicle or Bzb injections for 4 wk after focal radiation based on static histomorphometry (n = 5 mice/group). B) MS and BFR were quantified based on dynamic histomorphometry (n = 5 mice/group). aP < 0.05, bP < 0.01, cP < 0.001 R vs. NR; *P < 0.05, #P < 0.001 Bzb vs. veh. C) Representative images show double labels, xylenol orange (red) and calcein (green), in trabecular bone after radiation and Bzb treatment. D) Bzb reduces the number of osteoclasts regardless of radiation (n = 5 mice/group). aP < 0.05, bP < 0.01 vs. veh NR. E) Serum osteocalcin (Ocn) and CTX-I levels in mice with or without Bzb treatment for 4 wk post irradiation were quantified (n = 9 mice/group). NR, nonirradiated; R, irradiated; veh, vehicle. aP < 0.05 vs. veh.