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. Author manuscript; available in PMC: 2017 Dec 15.
Published in final edited form as: Acta Trop. 2017 Jun 9;173:102–108. doi: 10.1016/j.actatropica.2017.06.004

Fig. 2.

Fig. 2

Evaluation of efficacy of topical nanoliposomal Amphotericin B treatment on L. mexicana infected BALB/c and 129SVE mice. BALB/c and 129SVE mice were infected with 5 × 106 stationary phase L. mexicana promastigotes via subcutaneous injection in their shaven back rumps. After mice developed ulcerated lesions (BALB/c at week 8 and 129SVE at week 5), mice with similar sized lesions were randomized and treated with SinaAmphoLeish 0.4% or Vaseline (control) twice a day. Representative images BALB/c (A) and 129SVE (E) mice with back rump lesions from treatment and control groups. Lesion sizes of BALB/c (B) and 129SVE (F) mice expressed as mean lesion sizes (millimeters2) ± SE. Parasitic loads expressed as the largest log dilution that represents live parasites in cultures obtained from lesions of BALB/c (C) and 129SVE (G) mice. Parasitic loads expressed as the largest log dilution that represents live parasites in cultures obtained from lymph nodes of BALB/c (D) and 129SVE (H) mice. Data represents the means ± SE from one of the two similar experiments (n = 5 mice per group). * p < 0.05 (Students unpaired t-test).