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. Author manuscript; available in PMC: 2017 Dec 15.
Published in final edited form as: J Med Chem. 2017 Sep 19;60(18):7876–7896. doi: 10.1021/acs.jmedchem.7b01009

Scheme 6.

Scheme 6

Reagents and conditions: (i) dimethylformamide dimethyl acetal, anhydrous DMF, rt, overnight; (ii) appropriate phosphorochloridate, tBuMgCl, anhydrous THF/pyridine, rt, 16 h; (iii) 2-propanol, reflux, 24–72 h.