Figure 5.

Δ⁹‐THCA prevents mutated huntingtin‐induced cytotoxicity via PPARγ. (A) Serum deprivation induces neuronal death in STHdh ^Q111/Q111 but not in STHdh ^Q7/Q7 cells. Cellular viability was measured by the MTT method (n = 5). (B) Δ⁹‐THCA and rosiglitazone (RGZ) prevent cell death induced by serum deprivation. STHdh ^Q111/Q111 cells were cultured under serum deprivation conditions and treated with Δ⁹‐THCA in the absence or the presence of the PPARγ antagonist GW9662 (5 μM). Cell viability was calculated using the MTT method and referred to control cells (n = 5). ^* P < 0.05, significantly different from untreated cells; ^# P < 0.05, significantly different from serum‐starved cells; ^† P < 0.05, significantly different from serum‐starved cells treated with Δ⁹‐THCA.