Figure 6.

Δ⁹‐THCA is neuroprotective in 3‐NPA‐treated mice. (A) Behavioural score was determined 12 h after 3‐NPA injections. Mice were treated with Δ⁹‐THCA (20 mg·kg⁻¹). Hindlimb clasping, general locomotor activity, hindlimb dystonia and kyphosis were measured, and values are expressed as means ± SEM (n = 9). (B) Δ⁹‐THCA down‐regulates the expression of inflammatory genes in mice brain. RNA was isolated from the striatum, retrotranscribed and analysed by real‐time PCR. Tnf‐α, Inos, Il‐6 and Cox‐2 gene were studied. ^* P < 0.05, significantly different from control group; ^# P < 0.05, significantly different from 3‐NPA only group; ^† P < 0.05, significantly different from 3‐NPA plus Δ⁹‐THCA group (n = 9 animals per group).