Table 1.
Expression of Hepatocellular Differentiation Markers in ACCs
|
Staining Pattern, No.
|
|||||
|---|---|---|---|---|---|
| Marker | Pure ACC | MANEC | MADC | MANEDC | Total No. of Cases |
| Arginase 1 | 0 | 0 | 0 | 0 | 0 |
| Glypican 3 | 2 (1 patchy, 1 diffuse) | 4 (2 patchy, 2 diffuse) | 0 | 0 | 6 |
| AFP | 2 (patchy) | 2 (1 patchy, 1 diffuse) | 1 (diffuse) | 0 | 5 |
| HepPar 1 | 0 | 1 (patchy) | 0 | 0 | 1 |
| Albumin ISH | 1 | 3 | 1 | 0 | 5 |
ACC, acinar cell carcinoma; AFP, α-fetoprotein; HepPar 1, hepatocyte paraffin antigen 1; ISH, in situ hybridization; MADC, mixed acinar ductal carcinoma; MANEC, mixed acinar neuroendocrine carcinoma; MANEDC, mixed acinar, neuroendocrine, and ductal carcinoma.