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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2017 May 30;1860(1):40–47. doi: 10.1016/j.bbamem.2017.05.018

Figure 3. Prospective mechanism of action for GJA1-20k truncated isoform.

Figure 3

The internally translated CJA1-20k isoform is associated with the ER and dynamic vesicles, forming highly organized contacts with F-actin and microtubule networks. GJA1-20k interacts with F-actin, provides stabilization of filamentous actin and microtubules. F-actin disruption by oxidative stress or Latrunculin A impairs growth trajectories of the EB1/microtubule-based trafficking machinery, and decreases GJ localization to the cellular border, which can be rescued by exogenous GJA1-20k.