Table 4.
Studies Which Assessed Center Volume in Association With Graft and Patient Survival.
| Study | Number of centers and patients | Patient volume definition | Patient volume categories | Time point reported | Average survival rate | Effect measure | |
|---|---|---|---|---|---|---|---|
| Graft survival | |||||||
| Weng34 | 35 | 1779 | Categoricala | ≤95 vs >95 (reference) ≤95 vs >95 (reference) |
1 year 10 years |
NR NR |
OR: b3.17, 95% CI: 1.85-5.46 Log-rank P < .0001 |
| Tsao35 | 29 | 1060 | Categorical Volume is over study period |
≤72 vs >72 ≤72 vs >72 ≤72 vs >72 |
1 year 2 years 3 years |
85.8 vs 89.5 74.6 vs 81 73.3 vs 80.5 |
Log-rank P = .132 Log-rank P = .036 Log-rank P = .019 |
| Gjertson12 | 246 | 14 406 | Continuous Volume is over study period |
N/A | NR | N/A | NR |
| Kim6 | 20 | 5082 | Categorical Volume is over study period |
0-199 200-399 >400 (reference) |
NR | NR | HR: 1.28, 95% CI: 1.12-1.47 HR: 1.07, 95% CI: 0.94-1.22 HR: 1.0 (reference) |
| Axelrod20 | 258 | 60 778 | Categorical Volume is per year |
1-45, 46-75, 76-124, 125-278 (reference) |
1 year | 90.4 90.1 90.3 91.4 |
OR: b1.22, 95% CI: 1.01-1.48 OR: 1.22, 95% CI: 1.01-1.48 OR: 1.21, 95% CI: 0.99-1.49 OR: 1.0 (reference) Chi-square,P = .0014 |
| Briganti11 | 16 | 1986 | Categorical Volume is over study period |
1-99, 100-199, 200 |
NR | NR NR NR |
NR |
| Gjertson21 | 234 | 21 830 | Categoricala | ≤100, 101-400, >400 |
NR | NR NR NR |
NR |
| Gjertson22 | 144 | 8422 | Continuous Volume is over the study period |
N/A | NR | Data not extractable from figure | Log-rank P < .0001 |
| Schurman23 | 104 | 4715 | Categorical Volume is over study period |
≤50 51-100 >100 ≤50 51-100 >100 |
b3 months 5 years |
88.4 (0.9)b
90.2 (0.7) 90.4 (0.8) 65.5 (1.8) 69.4 (1.5)68.4 (1.6) |
NR |
| Terasaki24 | 254 | 120 262 | Categoricala | >1000 other |
NR | NR | NR |
| Morris32 | 23 | 6363 | Not reported | NR | NR | NR | NR |
| Hunsicker26 | NR | NR | Categorical Volume is over study period |
<25 25-50, 51-80, 81-150 (reference) >150 |
1 year | NR NR NR NR NR |
OR: b1.0 OR: 1.1 OR: 1.1 P < .05 OR: 1.0 (reference) OR: 1.0 |
| Gjertson27 | 223 | 35 625 | Continuous Volume is over the study period |
N/A | NR | N/A | NR |
| Evans28 | 145 | 9853 | Categorical Volume is per year |
<35 | NR | NR | NR |
| Ogura7 | 118 | 19 095 | Categorical Volume is over study period |
50-100, 100-150, >150 |
NR | NR | NR |
| Sanfilippo29 | 42 | 3811 | Continuous Average transplant number per center per year |
N/A | NR | N/A | NR |
| Opelz9 | 179 | 4547 | Continuous Volume is over study period |
||||
| Study | Number of centers and patients | Volume definition | Volume categories | Time point | Average survival rate | Effect measure | |
| Patient survival | |||||||
| Tsao35 | 29 | 1060 | Categorical Volume is over study period |
<72 vs >72 <72 vs >72 <72 vs >72 |
1 year 2 years 3 years |
91.2 vs 96.3 87.1 vs 94.1 85.4 vs 93.5 |
Log-rank P = .002 Log-rank P = .001 Log-rank P = .002 |
| Kim6 | 20 | 5082 | Categorical Volume is over study period |
0-199 200-399 >400 (reference) |
NR | HR: 1.33, 95% CI: 1.1-1.61 HR: 0.96, 95% CI: 0.79-1.16 HR: 1.0 (reference) |
|
| Evans28 | 145 | 9853 | Volume is over the study period | NR | NR | NR | NR |
| Sanfilippo29 | 42 | 3811 | Continuous Average transplant number per center per year |
N/A | NR | N/A | NR |
Note. HR = hazard ratio; OR = odds ratio; CI = confidence interval; NR = not reported; N/A = not applicable.
a
Study does not report time period of volume.
b
Adjusted analyses.
c
Reports standard error.