Table 1.

PH specialist medicines: administration, dosing, and complexity.

Medicine	Medicine class	Administration route	Dosing frequency	Complexity
Sildenafil	PDE5i	Oral tablet	Three times daily
Tadalafil	PDE5i	Oral tablet	Once daily
Bosentan	ERA	Oral tablet	Twice daily	Requires monthly blood test for liver function
Ambrisentan	ERA	Oral tablet	Once daily	Requires monthly blood test for liver function
Macitentan	ERA	Oral tablet	Once daily	Requires monthly blood test for liver function
Iloprost	Prostanoid	Nebulizer	Seven times a day (every 3 h while awake)	Nebulizer set-up and frequent cleaning
Epoprostenol	Prostanoid	Intravenous (IV) infusion	Continuous infusion changed 12–48 hourly	IV line care and multiple step reconstitution process
Treprostinil	Prostanoid	Nebulizer, IV or subcutaneous (SC)	Four times a day nebulizer, continuous IV or SC infusion	Nebulizer set-up and frequent cleaning, IV line care, SC site care
Selexipag	IPRA	Oral tablet	Twice daily
Riociguat	SGCS	Oral tablet	Three times daily

PDE5i, phosphodiesterase type-5 inhibitor; ERA, endothelin antagonist; IPRA, IP receptor agonist; SGCS, soluble guanylate cyclase stimulator.