Fig 8. Complexes that are more active have lever-arms with a reduced mobility.

a) RMSF values of chain A residues of S1, S2, S3 and S4 systems. b) RMSF values of chain B residues of S1, S2, S3 and S4 systems. The secondary structure of GR DBD is schematized along the x-axis. c) Principal Component Analysis of MD trajectories: projection on the first two eigenvectors of lever arm and D-loop CA atoms in S1, S2, S3 and S4 systems.