Table 2. Concentrations of angiogenic factors in maternal plasma.
| Group I–Pregnancies without Down syndrome (n = 28) | Group II–Pregnancies with Down syndrome (n = 20) | P-value | |
|---|---|---|---|
| Angiogenic factors concentration (pg/ml) Mean ± SEM |
Group I- Group II |
||
| Activin-A | 1249. 86 ± 426.49 | 2572.85 ± 1460.47 | 0.6098 |
| AgRP | 551.52 ± 146.31 | 520.77 ± 92.23 | 0.767 |
| Angiogenin | 6876.47 ± 1290.16 | 6054.87 ± 1354.91 | 0.5931 |
| ANG-2 | 3866.02 ± 338.3 | 3181.5 ± 294.15 | 0.2844 |
| ANGPLT4 | 79867.36 ± 14780.22 | 103653 ± 34218.56 | 0.9125 |
| bFGF | 489.66 ± 56.1 | 760.92 ± 124.44 | 0.0916 |
| ENA-78 | 4664.2 ± 842.18 | 2885.99 ± 602.66 | 0.1685 |
| GRO | 363.17 ± 51.75 | 567.12 ± 101.21 | 0.0574 |
| HB-EGF | 6.55 ± 1.75 | 40.38 ± 26.73 | 0.0938 |
| HGF | 372.31 ± 38.56 | 533.04 ± 106.51 | 0.6314 |
| IFN-gamma | 336.55 ± 36.4 | 385.78 ± 75.24 | 0.7682 |
| IGF-I | 17424.73 ± 2373.29 | 20000.79 ± 3554.24 | 0.9601 |
| IL-1a | 187.21 ± 26.77 | 266.44 ± 72.22 | 0.4404 |
| IL-2 | 554.63 ± 79.27 | 713.13 ± 153.98 | 0.3851 |
| IL-6 | 162.31 ± 13.28 | 193.75 ± 26.09 | 0.7449 |
| IL-8 | 88.07 ± 8.48 | 106.54 ± 12.99 | 0.3068 |
| IL-17 | 557.65 ± 129.12 | 800.92 ± 183.13 | 0.358 |
| IP-10 | 101.003 ± 68.35 | 91.9 ± 36.57 | 0.8008 |
| Leptin | 11825.51 ± 1484.38 | 14814.36 ± 3998.67 | 0.873 |
| LIF | 1260.48 ± 282.37 | 2567.52 ± 898.91 | 0.2898 |
| MCP-1 | 99.47 ± 11.22 | 141.08 ± 30.24 | 0.7015 |
| PDGF-BB | 425.16 ± 52.21 | 453.9 ± 96.12 | 0.671 |
| PIGF | 445.49 ± 60.006 | 598.81 ± 122.5 | 0.6454 |
| RANTES | 3853.96 ± 982.76 | 6664.86 ± 2213.77 | 0.2399 |
| TGFb1 | 9776.61 ± 1268.2 | 14464.41 ± 2025.33 | 0.039** |
| TIMP-1 | 40833.58 ± 3103.84 | 33269.67 ± 3052.19 | 0.0894 |
| TIMP-2 | 11131.3 ± 834.08 | 12615.48 ± 1529.79 | 0.6962 |
| TNF-alpha | 471.31 ± 121.27 | 641.41 ± 188.49 | 0.1137 |
| TNF-beta | 156.1 ± 28.17 | 274.62 ± 114.01 | 0.5716 |
| TPO | 11662.06 ± 1367.79 | 14576.39 ± 2867.99 | 0.6061 |
| ANG-1 | 401.61 ± 105.25 | 398.18 ± 100.48 | 0.9836 |
| Angiostatin | 183088.02 ± 8761.9 | 218713.15 ± 10762.9 | 0.0142* |
| CXCL16 | 569.76 ± 53.1 | 727.91 ± 89.3 | 0.1473 |
| EGF | 6.77 ± 1.31 | 12.95 ± 3.44 | 0.186 |
| FGF-4 | 3156.65 ± 1160.05 | 16633.63 ± 8734.45 | 0.1673 |
| Follistatin | 17023.61 ± 2703.59 | 19053.72 ± 3452.04 | 0.7814 |
| G-CSF | 2766.98 ± 745.4 | 3648.46 ± 1590.008 | 0.772 |
| GM-CSF | 36.42 ± 12.37 | 42.94 ± 19.89 | 1 |
| I-309 | 25.93 ± 4.05 | 60.42 ± 15.01 | 0.0476* |
| IL-1b | 60.97 ± 10.19 | 93.96 ± 25.29 | 0.9917 |
| IL-4 | 46.26 ± 4.02 | 50.52 ± 6.09 | 0.5432 |
| IL-10 | 12.12 ± 2.008 | 19.71 ± 6.48 | 0.5848 |
| IL-12p40 | 587.85 ± 96.97 | 1342.87 ± 493.5 | 0.6621 |
| IL-12p70 | 24.74 ± 3.13 | 31.54 ± 4.73 | 0.2227 |
| I-TAC | 42.05 ± 4.06 | 107.24 ± 35.36 | 0.6299 |
| MCP-2 | 49.07 ± 7.2 | 77.56 ± 26.86 | 0.5313 |
| MCP-3 | 60.52 ± 13.14 | 264.09 ± 128.14 | 0.5382 |
| MCP-4 | 406.6 ± 30.34 | 599.45 ± 121.46 | 0.6862 |
| MMP-1 | 1933.57 ± 218.86 | 3412.24 ± 1048.31 | 0.9257 |
| MMP-9 | 8957.7 ± 1631.17 | 9643.38 ± 1873.76 | 0.4984 |
| PECAM-1 | 2286.03 ± 285.81 | 3207.37 ± 709.82 | 0.5686 |
| TGFa | 901.39 ± 329.31 | 1916.84 ± 556.24 | 0.6227 |
| TGFb3 | 275.87 ± 61.11 | 2982.95 ± 1738.1 | 0.0395** |
| Tie-1 | 5181.73 ± 1903.04 | 20930.82 ± 7137.43 | 0.1115 |
| Tie-2 | 357.31 ± 43.91 | 691.69 ± 189.69 | 0.4521 |
| uPAR | 3004.43 ± 268.21 | 4427.4 ± 858.59 | 0.6116 |
| VEGF | 790.81 ± 71.37 | 922.94 ± 221.57 | 0.3664 |
| VEGF-R2 | 2219.33 ± 162.15 | 2535.33 ± 263.23 | 0.5271 |
| VEGF-R3 | 536.32 ± 72.25 | 1265.24 ± 392.09 | 0.4368 |
| VEGF-D | 201.25 ± 145.92 | 1624.53 ± 671.27 | 0.0173** |
* statistically significant value of < 0.05 for Student’s T-test
** statistically significant value of < 0.05 for Mann-Whitney Wilcoxon’s test