Table 2. Univariate and multivariate analyses of OS in patients with primary uveal melanoma.
| Parameters | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| p | HR | 95%CI (lower/upper) | p | HR | 95%CI (lower/upper) | |||
| Age > 60 vs.≤ 60 |
0.080 | 2.123 | 0.914 | 4.933 | 0.039 | 2.599 | 1.049 | 6.437 |
| Female vs. Male | 0.325 | 0.649 | 0.274 | 1.536 | ||||
| Histological type Epithelioid cell dominant vs. Spindle Cell dominant | 0.001 | 4.551 | 1.814 | 11.418 | 0.006 | 4.385 | 1.514 | 12.703 |
| Pathological stage III/IV vs. II |
0.358 | 1.504 | 0.630 | 3.589 | ||||
| Tumor diameter (mm) >16 vs. ≤16 |
0.192 | 1.831 | 0.738 | 4.541 | ||||
| Tumor thickness (mm) >10 vs. ≤10 |
0.106 | 2.106 | 0.854 | 5.191 | ||||
| Extrascleral extension No vs. Yes |
0.008 | 0.219 | 0.071 | 0.675 | 0.125 | 0.392 | 0.118 | 1.297 |
|
PVT1 expression High vs. Low |
0.0003 | 9.748 | 2.872 | 33.080 | 0.009 | 12.015 | 1.854 | 77.876 |
|
PVT1 DNA methylation High vs. Low |
0.0006 | 0.148 | 0.050 | 0.443 | 0.751 | 1.317 | 0.240 | 7.231 |