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Absence of PLIN2 prevents Etoh-induced, long-chain ceramide up-regulation in LDs. A) PLIN2 and PLIN3 immunoblots of LDs isolated from wild-type (WT) or PLIN2-null mice fed Ctrl or Etoh diets for 4 wk. B, C) Mass spectrometric analysis of total long-chain ceramides (B) and individual ceramide species (C) in LDs isolated from WT and PLIN2-null mice fed Ctrl or Etoh diets; n = 5 mice/group. KO, knockout. *P ≤ 0.05, **P ≤ 0.01.
