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. 2016 Jul 28;8(60):100975–100988. doi: 10.18632/oncotarget.10900

Figure 2. Introduction of miR-449a suppresses CRC cell growth and promotes apoptosis in vitro and in vivo.

Figure 2

(A) The mRNA level of miR-449a in HCT116 cells stably expressing the negative control or miR-449a. (B) MTT results of HCT116 cells stably expressing miR-449a or the negative control on the indicated days. (C) Annexin V/7-AAD flow cytometry results of HCT116 cells stably expressing miR-449a or the negative control. (D) Tumor growth in mice injected with HCT116 cells stably expressing miR-449a or the negative control. (E) Tumor weight (left) and volume (right) in mice injected with HCT116 cells stably expressing miR-449a or the negative control (n = 10). (F) Immunohistochemistry results for p27 and Ki67. TUNEL assays of tumors derived from HCT116 cells stably expressing miR-449a or the negative control.