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. 2017 Sep 19;8(60):100989–101004. doi: 10.18632/oncotarget.21054

Figure 2. Aerobic training effects on proliferation, apoptosis, and Hif1-α in mouse breast tumors.

Figure 2

A. Effects of aerobic training on tumor cell proliferation compared to control by Ki-67 index. (Left) Proliferation of tumor cells in EO771 tumors, (Middle) Proliferation of tumor cells in 4TO7 tumors, (Right) Proliferation of tumor cells in C3(1)Tag-p16-luc tumors. Values are mean ± S.E.M. (n = 10-13/group); *p < 0.05. B. Effects of aerobic training on tumor cell apoptosis compared to control. (Left) Apoptosis of tumor cells within EO771 tumors, (Middle) Apoptosis of tumor cells within 4TO7 tumors, (Right) Apoptosis of tumor cells within C3(1)Tag-p16-luc tumors. Values are mean ± S.E.M. (n = 10-13/group). C. Western blot of Hif1-α in mouse tumors: Hif1-α western blot in C3(1)SV40Tag-p16-luc tumors (Bottom Left), EO771 tumors (Bottom Right) C3(1)SV40Tag-p16-luc mouse tumors: Mean densitometry normalized to β-actin : Aerobic Training, 17.11; Control, 1.45; (p = 0.06), EO771 mouse tumors: Mean densitometry normalized to β-actin : Aerobic Training, 6.02; Control, 1.19; (p = 0.04).