Table 3. Multivariate Cox analysis of cancer-specific survival and overall survival for the different growth patterns of intrahepatic cholangiocarcinoma.

Characteristic	Cancer-specific survival						Overall survival
	MF-type			PI-type			PI-type
	HR	95% CI	pa	HR	95% CI	pa	HR	95% CI	pa	HR	95% CI	pa
Age (years)
≤ 60	1			1			1			1
> 60	1.505	1.260–1.798	< 0.001	1.888	1.029–3.463	0.040	1.543	1.299–1.834	< 0.001	2.058	1.127–3.757	0.019
Race
White	1			1			1			1
Black	1.243	0.913–1.691	0.168	1.078	0.503–2.311	0.846	1.210	0.895–1.636	0.215	1.008	0.474–2.142	0.984
Other	0.942	0.742–1.197	0.626	1.235	0.546–2.790	0.612	0.989	0.789–1.240	0.925	1.364	0.627–2.969	0.434
Sex
Male	1			1			1			1
Female	0.887	0.748–1.053	0.171	0.804	0.451–1.432	0.458	0.880	0.746–1.038	0.130	0.710	0.404–1.247	0.233
Marital status
Married	1			1			1			1
Not married	1.093	0.922–1.296	0.303	0.838	0.467–1.504	0.554	1.112	0.944–1.310	0.202	0.842	0.477–1.485	0.552
Histologic grade
Grade I + II	1			1			1			1
Grade III + IV	1.574	1.333–1.859	< 0.001	2.583	1.483–4.499	0.001	1.560	1.329–1.832	< 0.001	2.398	1.400–4.107	0.001
AJCC stage (8th edition, 2017)
Stage I	1			1			1			1
Stage II	1.766	1.341–2.326	< 0.001	0.969	0.371–2.534	0.949	1.760	1.356–2.285	< 0.001	0.832	0.323–2.141	0.703
Stage III	2.176	1.657–2.858	< 0.001	1.837	0.847–3.987	0.124	2.073	1.597–2.691	< 0.001	1.543	0.729–3.267	0.257
Stage IV	2.397	1.846–3.113	< 0.001	1.971	0.864–4.496	0.107	2.315	1.804–2.971	< 0.001	2.018	0.909–4.478	0.084
Surgery performed
Performed	1			1			1			1
Not performed	4.115	3.321–5.098	< 0.001	2.897	1.424–5.891	0.003	3.938	3.210–4.830	< 0.001	2.784	1.392–5.569	0.004

Abbreviations: AJCC, American Joint Committee on Cancer; MF, mass-forming; PI, periductal infiltrating.

^a Bold type indicates statistical significance.