Table 4. Comparison of cancer-specific survival and overall survival between the MF-type and PI-type of intrahepatic cholangiocarcinoma after subgroup analyses using a multivariate Cox proportional hazard model.
| AJCC stage (8th edition, 2017) | Cancer-specific survival | Overall survival | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | pa | HR | 95% CI | pa | |
| stage I | ||||||
| MF-type (n = 597) | 1 | 1 | ||||
| PI-type (n = 48) | 1.941 | 1.141–3.302 | 0.014 | 1.985 | 1.202–3.280 | 0.007 |
| stage II | ||||||
| MF-type (n = 533) | 1 | 1 | ||||
| PI-type (n = 28) | 1.188 | 0.515–2.739 | 0.687 | 1.038 | 0.452–2.383 | 0.931 |
| stage III | ||||||
| MF-type (n = 498) | 1 | 1 | ||||
| PI-type (n = 40) | 1.296 | 0.728–2.307 | 0.378 | 1.214 | 0.685–2.153 | 0.506 |
| stage IV | ||||||
| MF-type (n = 852) | 1 | 1 | ||||
| PI-type (n = 83) | 1.085 | 0.714–1.650 | 0.702 | 1.104 | 0.737–1.652 | 0.632 |
| MF of stage II vs. PI of stage I | ||||||
| stage II MF-type (n = 533) | 1 | 1 | ||||
| stage I PI-type (n = 48) | 1.208 | 0.719–2.031 | 0.475 | 1.206 | 0.737–1.972 | 0.456 |
Abbreviations: AJCC, American Joint Committee on Cancer; MF, mass–forming; PI, periductal infiltrating.
aThe P value was adjusted using a multivariate Cox proportional hazard regression model that accounted for age, race, sex, marital status, histologic grade, and surgery status. Bold type indicates statistical significance.