Table 4. Signaling pathway analysis of the genetic interaction network associated with liver-aggressive explant in terms of Gene Ontology (GO).
| Pathway ID | Signaling pathway | Observed Gene Count | FDR |
|---|---|---|---|
| 4010 | MAPK signaling pathway | 16 | 1.42E-12 |
| 4668 | TNF signaling pathway | 9 | 7.29E-08 |
| 5014 | Amyotrophic lateral sclerosis (ALS) | 7 | 1.26E-07 |
| 4750 | Inflammatory mediator regulation of TRP channels | 8 | 3.45E-07 |
| 4380 | Osteoclast differentiation | 8 | 1.45E-06 |
| 5140 | Leishmaniasis | 6 | 1.24E-05 |
| 4721 | Synaptic vesicle cycle | 5 | 0.000104 |
| 4664 | Fc epsilon RI signaling pathway | 5 | 0.000156 |
| 4660 | T cell receptor signaling pathway | 5 | 0.000787 |
| 5146 | Amoebiasis | 5 | 0.000993 |
| 4060 | Cytokine-cytokine receptor interaction | 7 | 0.00133 |
| 4722 | Neurotrophin signaling pathway | 5 | 0.00145 |
| 5160 | Hepatitis C | 5 | 0.00206 |
| 4015 | Rap1 signaling pathway | 6 | 0.00207 |
| 4911 | Insulin secretion | 4 | 0.00355 |
| 4728 | Dopaminergic synapse | 4 | 0.0148 |
| 5131 | Shigellosis | 3 | 0.0148 |
| 4370 | VEGF signaling pathway | 3 | 0.0155 |
| 5162 | Measles | 4 | 0.0162 |
| 5120 | Epithelial cell signaling in Helicobacter pylori infection | 3 | 0.0194 |
| 5222 | Small cell lung cancer | 3 | 0.0351 |
| 4064 | NF-kappa B signaling pathway | 3 | 0.0384 |
| 5168 | Herpes simplex infection | 4 | 0.0384 |
| 4723 | Retrograde endocannabinoid signaling | 3 | 0.0473 |
Abbreviations: FDR, false discovery rate; GO, Gene Ontology.