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. 2017 Oct 23;8(60):101808–101831. doi: 10.18632/oncotarget.21981

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Copyright: © 2017 Ciribilli and Borlak

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A–E) Kaplan–Meier curves of lung adenocarcinoma (left panels) and lung squamous cell carcinoma (right panels) were generated using KM-plotter tool by considering the expression of down-regulated genes in c-Myc transgenic lung tumors. Red and black curves always represent patients with high and low expression levels, respectively, of the selected gene. Given underneath each curve is the number of patients. Additionally, the Hazard Ratios and the p-values are shown in the plot. (E) A “13-gene signature” of strongly down-regulated genes (FC < –10 as average of the c-Myc transgenic PLAC tumors) was evaluated for clinical relevance in human lung cancers (see Supplementary Table 3).

(A–E) Kaplan–Meier curves of lung adenocarcinoma (left panels) and lung squamous cell carcinoma (right panels) were generated using KM-plotter tool by considering the expression of down-regulated genes in c-Myc transgenic lung tumors. Red and black curves always represent patients with high and low expression levels, respectively, of the selected gene. Given underneath each curve is the number of patients. Additionally, the Hazard Ratios and the p-values are shown in the plot. (E) A “13-gene signature” of strongly down-regulated genes (FC < –10 as average of the c-Myc transgenic PLAC tumors) was evaluated for clinical relevance in human lung cancers (see Supplementary Table 3).