Table 2. Univariate and multivariate analysis of prognostic factors of OS.
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% Cl) | p value | HR (95 % Cl) | p value | |
| RNF187 expresssion (positive vs negative) | 1.766(1.157–2.696) | 0.008 | 0.810 (0.478–1.375) | 0.436 |
| Tumor diameter (cm) (≤ 5 vs > 5) | 1.725 (1.133–2.628) | 0.011 | 0.805(0.395–1.409) | 0.367 |
| Tumor number (1 vs. ≥ 2) | 3.018 (1.917–4.749) | 1.81E-6 | 1.099(0.570–2.121 ) | 0.778 |
| Vascular invasion (positive vs negative) | 2.392 (1.555–3.679) | 7.21E-5 | 1.453(0.857–2.464) | 0.166 |
| AFP (ng/ml) (≤ 400 vs > 400) | 1.427 (0.906–2.248) | 0.125 | n.a. | |
| TNM stage (I-II vs III-IV) | 6.461 (4.170–10.01) | 6.63E-17 | 4.922(2.759–5.621) | 5.63E-8. |
| Tumor differentiation | 5.608 (3.625–8.674) | 9.43E-15 | 3.478(2.085–5.495) | 8.13E-7 |
| Sex (male vs female) | 1.776 (0.891–3.544) | 0.103 | n.a. | |
| Liver cirrhosis (positive vs negative) | 0.748 (0.345–1.620) | 0.462 | n.a. | |
| ALT (U/L) (≤ 50 vs > 50) | 1.003 (0.545–1.846) | 0.993 | n.a. | |
| Age (years) (≤ 50 vs > 50) | 1.766 (0.891–3.544) | 0.103 | n.a. | |
| HBsAg (positive vs negative) | 0.817 (0.491–1.358) | 0.435 | n.a. | |
Abbreviations and Note: HCC, hepatocellular carcinoma; AFP, alpha-fetoprotein; TNM, tumor node metastasis; HBsAg, hepatitis B surface antigen; ALT, alanine aminotransferase; n.a., not applicable; The X2 test was used for comparison between groups. 50 % for RNF187.