Table 3. Univariate and multivariate analysis of prognostic factors of DFS.
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95%Cl) | p value | HR (95% Cl) | p value | |
| RNF187 expresssion (positive vs negative) | 2.137 (1.404–3.253) | 3.97E-4 | 1.142 (0.687–1.900) | 0.608 |
| Tumor diameter (cm, ≤ 5 vs > 5) | 1.110 (1.055–1.167) | 5.24E-5 | 1.252 (0.696–2.176) | 0.476 |
| Tumor number (1 vs. ≥2) | 1.618 (1.100–2.380) | 0.015 | 1.251 (0.673–2.328 ) | 0.478 |
| Vascular invasion (positive vs negative) | 2.544 (1.674–3.867) | 1.22E-5 | 1.594 (0.883–2.416) | 0.025 |
| AFP (ng/ml, ≤ 400 vs > 400) | 1.151 (0.810–1.263) | 0.160 | na | |
| TNM stage (I–II vs III–IV) | 4.211 (2.756–6.433) | 2.94E-11 | 2.332 (1.304–4.171) | 0.004 |
| Tumor differentiation | 3.273 (2.147–4.990) | 3.53E-8 | 1.809 (1.096–2.985) | 0.002 |
| Sex (male vs. female) | 1.441 (0.766–2.708) | 0.257 | n.a. | |
| Liver cirrhosis (positive vs negative) | 0.677 (0.313–1.465) | 0.322 | n.a. | |
| ALT (U/L, ≤ 50 vs > 50) | 0.684 (0.343–1.362) | 0.280 | n.a. | |
| Age (years, ≤ 50 vs > 50) | 1.236 (0.809–1.889) | 0.327 | n.a. | |
| HBsAg (positive vs negative) | 1.057 (0.623–1.791) | 0.838 | n.a. | |
Abbreviations and Note: HCC, hepatocellular carcinoma; AFP, alpha-fetoprotein; TNM, tumor node metastasis; HBsAg, hepatitis B surface antigen; ALT, alanine aminotransferase; n.a., not applicable; The X2 test was used for comparison between groups. 50 % for RNF187.