. 2017 Oct 9;8(60):101887–101898. doi: 10.18632/oncotarget.21710

Table 2. Performance of surrogate peptide markers derived from 10 prostate cancer-associated secreted proteins in 20 urine samples (14 cancer and 6 non-cancer samples).

Protein	Peptide	(L/H)_{peptide marker}		(L/H)_{peptide marker}/(L/H)_PSA
Protein	Peptide	P value^a	AUC	P value^a	AUC	Sensitivity^b	Specificity^b
AGR2	LPQTLSR	0.773	0.45	0.063	0.77	0.93	0.67
AGR3	LYTYEPR	0.283	0.66	0.019	0.85	0.79	1
CEAM5	SDLVNEEATGQFR	0.322	0.65	0.012	0.87	0.71	1
CEAM6	EVLLLAHNLPQNR	0.246	0.67	0.029	0.82	0.79	0.83
CRISP3	WANQCNYR^c	0.386	0.63	0.035	0.86	0.86	0.83
CRISP3	YEDLYSNCK^c	0.433	0.38	0.035	0.81	0.64	1
CD90	VLYLSAFTSK	0.174	0.70	0.015	0.86	0.86	0.83
CD90	VTSLTACLVDQSLR^c	0.967	0.45	0.063	0.77	0.64	1
CD90	HVLFGTVGVPEHTYR	0.650	0.57	0.012	0.87	0.86	0.83
CXL14	MVIITTK	0.836	0.46	0.091	0.75	0.79	0.83
IL24	LWEAFWAVK	0.479	0.61	0.015	0.86	0.71	1
MMP9	AVIDDAFAR	1	0.50	0.029	0.82	0.93	0.67
MMP9	FQTFEGDLK	0.710	0.56	0.015	0.86	0.93	0.67
MMP9	LGLGADVAQVTGALR	0.869	0.47	0.015	0.86	0.86	0.83
MMP9	SLGPALLLLQK	1	0.49	0.015	0.86	0.85	0.83
SFRP4	GVCISPEAIVTDLPEDVK^c	0.592	0.42	0.023	0.83	0.64	1

^aP values were obtained from the Mann-Whitney U test.

^bThese are the sensitivity and specificity at the optimal cutoff point (i.e., the best sum of sensitivity and specificity).

^cCysteine was synthesized as carbamidomethyl cysteine.