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(A) overexpress TCTP in A549 repressed the protein level of P53 (left) but has little effect on the P53 mRNA level (right). (B) Repress the mRNA synthesis of P53 and overexpress TCTP doesn't lead to P53 protein level dramatically decrease compare with wildtype A549. (C) co-IP proved that TCTP can bind to P53. (D) with treatment of CHX, knockdown TCTP can keep the protein stability of P53.
