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. 2017 Oct 10;8(60):101922–101935. doi: 10.18632/oncotarget.21747

Figure 8. Signal pathways may involve in and the hypothesis.

Figure 8

(A) Compare with wildtype A549 cells (1), overexpress P53 (2) leads to decrease level of p-AKT. The repression was relieved with TCTP overexpression. (B) The phosphorylation of AKT was decreased in the TCTP knockdown cells with gamma irradiation. (C) Activate AKT with EGF, the sensitivity to ActD in TCTP knockdown cells was repressed and knockdown TCTP didn't reverse the effect. (D) Hypothesis of P53-TCTP feedback signal pathway in lung cancer.